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The method that is commonly misunderstood by experienced nurses as a means to reduce the risk of HIV transmission when handling blood and body fluids is double-gloving. While double-gloving can provide an additional layer of protection against percutaneous injuries and contamination, it is not specifically aimed at reducing the risk of HIV transmission. The primary way to prevent the transmission of HIV is through the use of gloves to protect against exposure to blood and body fluids, along with other standard precautions, rather than relying solely on wearing multiple pairs of gloves.

In the context of other options, wearing an N95 respirator is primarily intended for protection against airborne pathogens, rather than exposure to blood or body fluids. Using face shields helps protect the mucous membranes of the face but does not directly impact the risk associated with HIV transmission from blood. Using hand sanitizers after glove removal is a crucial practice for overall hand hygiene and preventing the spread of infections, but it does not substitute the need for gloves when working with potentially infectious materials. Thus, double-gloving is often misunderstood in its specific efficacy regarding HIV transmission.